|
Patent
|
Title
|
Country |
Patent number |
|
MetaMouse
|
Nude mouse model for human
neoplastic disease
|
US
|
5,491,284
|
|
MetaMouse
|
Nude mouse model for human
neoplastic disease
|
US
|
5,569,812
Reissue RE:39,337 |
|
MetaMouse
|
Animal model for human disease |
Japan
|
2,664,261
|
|
MetaMouse
|
Animal model for human disease |
Europe
|
437,488
|
|
HDRA
|
Noncolorimetric histoculture
method for predicting drug response of tumors
|
US
|
5,474,909
|
|
HDRA
|
Native-state method and system
for determining viability and proliferative capacity of tissues in
vitro
|
US
|
5,726,009
|
|
HDRA
|
Expression profiling
based on histoculture
|
US
|
7,252,941
|
|
HDRA
|
Native-state method and system for determining viability and
proliferative capacity of tissues in vitro |
Europe
|
714,448 |
|
HDRA
|
Expression profiling based on histoculture |
Europe
|
1,567,672 |
|
HDRA
|
Expression profiling based on histoculture |
Japan |
4,336,654 |
|
HDRA
|
Expression profiling based on histoculture |
China |
ZL200380108676.2 |
|
DermaTek
|
Native-state histoculturing
method for skin
|
US
|
5,849,579
|
|
DermaTek
|
Native-state histoculturing
method for skin
|
US
|
6,399,380
|
|
DermaTek
|
A native-state histoculturing
method for skin |
Europe
|
573,606
|
|
DermaTek
|
Method to provide for
production of hair coloring pigments in hair follicles
|
US
|
6,261,596
|
|
DermaTek
|
Method for delivering melanin
to hair follicles
|
US
|
5,641,508
|
|
DermaTek
|
Method to provide for
production of hair coloring
pigments in hair follicles
|
US
|
5,965,157
|
|
DermaTek
|
Method to introduce a
replacement pigment into the hair shaft through the hair follicle
|
US
|
6,224,901
|
|
DermaTek
|
Methods to deliver
macromolecules to hair follicles
|
US
|
5,914,126
|
|
DermaTek
|
Method to deliver compositions
conferring resistance to alopecia to hair
|
US
|
5,753,263
|
|
DermaTek
|
Method for delivering
beneficial compositions to hair follicles |
Canada
|
2159626
|
|
DermaTek
|
Method for delivering
beneficial compositions to hair follicles |
Europe
|
692972
|
|
DermaTek
|
Method and model for hair pigmentation |
Europe
|
1,127,121
|
|
DermaTek
|
Method for delivering
beneficial compositions to hair follicles |
Japan
|
2,950,519 |
|
DermaTek
|
Method for delivering
beneficial compositions to hair follicles |
Japan
|
2,950,520 |
|
DermaTek
|
Nestin-expressing
hair follicle stem cells |
US |
7,666,675 |
|
DermaTek
|
Nestin-expressing
hair follicle stem cells |
US |
8,481,318 |
|
DermaTek
|
Nestin-expressing
hair follicle stem cells |
Japan
|
3,978,179 |
|
DermaTek
|
Nestin-expressing
hair follicle stem cells |
China |
ZL02823052.3 |
|
DermaTek
|
Nestin-expressing
hair follicle stem cells |
Australia |
2002336742 |
|
DermaTek
|
Nestin-expressing
hair follicle stem cells |
South Korea |
10-973424 |
|
DermaTek
|
Skin vibration method for
topical targeted delivery of beneficial agents into hair follicles
|
US
|
5,830,177
|
|
DermaTek
|
Skin vibration method for
topical targeted delivery of beneficial agents into hair follicles
|
US
|
6,080,127
|
|
DermaTek
|
Skin vibration method for
topical targeted delivery of beneficial agents into hair follicles |
Australia
|
731,559
|
|
DermaTek
|
Method
for promoting hair growth
|
US
|
6,733,776 |
|
DermaTek
|
Method
for promoting hair growth
|
US
|
7,556,825 |
|
DermaTek
|
Treatment
of alopecia
|
US
|
6,844,326 |
|
DermaTek
|
Skin vibration
method for topical targeted delivery of beneficial agents into hair
follicles |
Canada
|
2,269,919 |
|
Methioninase
|
Methioninase gene therapy for
tumor treatment
|
US
|
6,524,571 |
|
Methioninase
|
Methioninase formulations and
use in diagnostic methods
|
US
|
6,231,854
|
|
Methioninase
|
Improved methioninase
formulations
|
US
|
5,888,506
|
|
Methioninase
|
Use of methioninase and
chemotherapy agents in chemotherapy |
US
|
5,690,929
|
|
Methioninase
|
Method to produce high levels
of methioninase
|
US
|
5,891,704
|
|
Methioninase
|
Use of methioninase as an
antitumor agent in antimethionine chemotherapy |
Europe |
668,933 |
|
Methioninase
|
High expression modules
containing two or more tandem copis of a methioninase encoding sequence |
Europe
|
1,005,557 |
|
Methioninase
|
High expression modules
containing two or more tandem copis of a methioninase encoding sequence |
Australia
|
752,107 |
|
Methioninase
|
Uses in methioninase as an
antitumor agent in anti-methionine chemotherapy |
Australia
|
687,768
|
|
Methioninase
|
Use of methioninase as an
antitumor agent in anti-methionine chemotherapy |
Japan
|
2,930,723
|
|
Methioninase
|
Methods for increasing polyethylene
glycol (PEG) conjugation |
Japan
|
5,460,958 |
|
Methioninase
|
Use of methioninase as an
antitumor agent in anti-methionine chemotherapy |
Europe |
1287830 |
|
Methioninase
|
High expression modules containing two
or more tandem copies of a methioninase encoding sequence |
Europe |
1005557 |
|
Methioninase
|
Recombinant L-methionine
gamma-lyase
|
US
|
5,861,154
|
|
Methioninase
|
Recombinant L-methionine
gamma-lyase
|
US
|
5,863,788
|
|
Methioninase
|
High expression modules
containing two or more tandem copies of a methioninase encoding sequence |
US
|
6,461,851 |
|
Methioninase
|
High expression modules
containing two or more tandem copies of a methioninase encoding sequence |
Canada
|
2299282 |
|
Methioninase
|
Modulators
of methylation for control of bacterial virulence |
US
|
6,632,430 |
|
Methioninase
|
Modulators
of methylation for control of bacterial virulence |
Europe
|
1183034 |
|
Methioninase
|
Modulators of
methylation for control of bacterial virulence |
Canada
|
2,375,383 |
|
Methioninase
|
Use of
methioninase in anti-methionine and anti-homocysteine chemotherapy |
Canada
|
2,149,776 |
|
Methioninase
|
Modulators of
methylation for control of bacterial virulence |
Canada
|
2,375,383 |
|
Methioninase
|
Methods for increasing polyethylene
glycol (PEG) conjugation |
Canada
|
2,560,259 |
|
Methioninase
|
Lyase treatment for P.
carinii |
US
|
7,264,819 |
|
Methioninase
|
Lyase treatment for P.
carinii |
Australia
|
2044251724 |
|
Methioninase
|
The use of methioninase to prepare a medicament
for treating P. Carinii infection |
China
|
ZL200480017595.6 |
|
Methioninase
|
Methods for
increasing polyethylene glycol (PEG) conjugation |
US
|
7,329,516 |
|
Methioninase
|
Methods for
increasing polyethylene glycol (PEG) conjugation |
US
|
8,465,734 |
|
Methioninase
|
Methods for
increasing polyethylene glycol (PEG) conjugation |
China
|
ZL200580015792.9 |
|
Methioninase
|
Methods for
increasing polyethylene glycol (PEG) conjugation |
Europe
|
1725583 |
|
Methioninase
|
Methods for
increasing protein polyethylene glycol (PEG) conjugation |
US
|
7,799,549 |
|
Methioninase
|
Schiff-base conjugate of N,Nibutyl-p-phenylenediamine with pyridoxal
5’-phosphate for improved homocysteine assays using pyridoxal
5’-phosphate-dependent enzymes |
US
|
9,464,312 |
|
GFP
|
Metastasis models using green
fluorescent protein (GFP) as a marker
|
US
|
6,232,523
|
|
GFP
|
Metastasis models using green
fluorescent protein (GFP) as a marker
|
US
|
6,235,967
|
|
GFP
|
Metastasis models using green
fluorescent protein (GFP) as a marker
|
US
|
6,235,968
|
|
GFP
|
Metastasis models using green
fluorescent protein (GFP) as a marker
|
US
|
6,251,384
|
|
GFP
|
Metastasis models using green
fluorescent protein (GFP) as a marker
|
US
|
6,759,038 |
|
GFP
|
Metastasis models using green
fluorescent protein (GFP) as a marker
|
Canada
|
2,358,439 |
|
GFP
|
Whole-body
optical imaging of gene expression and uses thereof |
US
|
6,649,159 |
|
GFP
|
Real
time measurement of cellular responses
|
US
|
6,905,831
|
|
GFP
|
Real
time measurement of cellular responses
|
Europe |
1546388
|
|
GFP
|
Real
time measurement of cellular responses
|
China |
03823937X
|
|
GFP
|
Real
time measurement of cellular responses
|
Australia |
2003272221
|
|
GFP
|
Real
time measurement of cellular responses
|
Canada |
2,495,411
|
|
GFP
|
Real
time measurement of cellular responses
|
Korea |
10-1488574
|
|
GFP
|
Real
time measurement of cellular responses
|
Korea |
10-1490647
|
|
GFP
|
Metastasis model using green
fluorescent protein (GFP) as a marker |
Australia |
749,338 |
|
GFP
|
Whole-body
optical imaging of gene expression and uses thereof |
Australia |
2001249297 |
|
GFP
|
Whole-body
optical imaging of gene expression and uses thereof |
Canada |
2403090 |
|
GFP
|
Metastasis model using green
fluorescent protein (GFP) as a marker |
Japan |
3,709,343 |
|
GFP
|
Whole-body
optical imaging of gene expression and uses thereof |
Japan |
4,021,197 |
|
GFP
|
Metastasis
models using green fluorescent protein (GFP) as a marker |
Europe |
0979298 |
|
GFP
|
Metastasis
models using green fluorescent protein (GFP) as a marker |
Europe |
1156833 |
|
GFP
|
Metastasis
models using green fluorescent protein (GFP) as a marker |
Canada |
2289283 |
|
GFP
|
Whole-body
optical imaging of gene expression and uses thereof |
Europe |
1294906 |
|
GFP
|
Whole-body
optical imaging of gene expression and uses thereof |
Germany |
60137501708 |
|
GFP
|
Whole-body
optical imaging of gene expression and uses thereof |
Korea |
10-868200 |
|
Homocysteine Assay
|
High specificity
homocysteinases and genes therefor
|
US
|
6,140,102
|
|
Homocysteine Assay
|
High
specificity homocysteine assays for biological samples
|
US
|
5,985,540
|
|
Homocysteine Assay
|
High specificity homocysteine
assays for biological samples
|
US
|
5,998,191
|
|
Homocysteine Assay
|
High specificity homocysteine
assays for biological samples
|
US
|
6,066,467
|
|
Homocysteine Assay
|
Synthesis of N,N-disubstituted-P-Phenylenediamine
|
US
|
6,448,446
|
|
Homocysteine Assay
|
High
specificity homocysteinases |
US
|
6,468,762 |
|
Homocysteine Assay
|
High
expression and production of high specific activity
recombinant S-adenosylhomocysteine (SAHH) and improved assays for
S-adenosylmethionine (SAM) |
US
|
6,713,273 |
|
Homocysteine Assay
|
METHOD TO DETERMINE THE LEVEL OF HYDROGEN SULFIDE IN A SAMPLE AND
METHOD TO IDENTIFY A SEQUENCE ENCODING A HOMOCYSTEINASE WITH A
DESIRED DEGREE OF SPECIFICITY |
Europe
|
1,210,443 |
|
Homocysteine Assay
|
High
expression and production of high specific activity
recombinant S-adenosylhomocysteine (SAHH) and improved assays for
S-adenosylmethionine (SAM) |
Europe
|
1,250,448 |
|
Homocysteine Assay
|
S-adenosylhomocysteine (SAHH) as a therapeutic agent for cancer |
Europe
|
1,997,508 |
|
Homocysteine Assay
|
METHOD TO DETERMINE THE LEVEL OF HYDROGEN SULFIDE IN A SAMPLE AND
METHOD TO IDENTIFY A SEQUENCE ENCODING A HOMOCYSTEINASE WITH A
DESIRED DEGREE OF SPECIFICITY |
Europe
|
1,210,443 |
|
Homocysteine Assay
|
High
expression and production of high specific activity
recombinant S-adenosylhomocysteine (SAHH) and improved assays for
S-adenosylmethionine (SAM) |
Japan
|
5058422 |
|
Homocysteine Assay
|
High
expression and production of high specific activity
recombinant S-adenosylhomocysteine (SAHH) and improved assays for
S-adenosylmethionine (SAM) |
Canada
|
2390057 |
|
Homocysteine Assay
|
Synthesis of N,N-disubstituted-P-Phenylenediamine
|
Europe |
1265846
|
|
Homocysteine Assay
|
Homocysteine enzymatic assay kit |
Japan |
3,337,693 |
|
Homocysteine Assay
|
High specificity homocysteine assays for biological samples |
Australia |
758729 |
|
Homocysteine Assay
|
Synthesis
of N,N-disubstituted-P-Phenylenediamine
|
Australia |
2001229460
|
|
Homocysteine Assay
|
Synthesis
of N,N-disubstituted-P-Phenylenediamine
|
Korea |
10-0682292
|
|
Homocysteine Assay
|
Synthesis
of N,N-disubstituted-P-Phenylenediamine
|
Japan |
4756806
|
|
Homocysteine Assay
|
Synthesis
of N,N-disubstituted-P-Phenylenediamine
|
Canada |
2389595 |
|
Homocysteine
Assay |
High
specificity homocysteine assays for biological samples
|
China |
ZL98807531.8
|
|
Homocysteine
Assay |
High
specificity homocysteine assays for biological samples
|
Europe |
1000170
|
|
Homocysteine
Assay |
High
specificity homocysteine assays for biological samples
|
Hong Kong |
HK1028263 |
|
Homocysteine
Therapy |
Use
of methioninase in anti-methionine and anti-homocysteine
chemotherapy
|
China |
ZL96190574.3
|
|
Homocysteine
Therapy |
Use
of methioninase in anti-methionine and anti-homocysteine
chemotherapy
|
Canada |
2,221,690 |
|
Cysteine Assay
|
Total
Cysteine Assay
|
US |
6,927,038
|
|
Cysteine Assay
|
Total
Cysteine Assay
|
China |
ZL02823051.5
|
|
Cysteine Assay
|
Total
Cysteine Assay
|
Europe |
1,456,399
|
|
Cysteine Assay
|
Total
Cysteine Assay
|
Australia |
2002346474
|
|
Cysteine Assay
|
Total
Cysteine Assay
|
Japan |
4319545
|
|
Cysteine Assay
|
Total
Cysteine Assay
|
Canada |
2,466,503
|
|
Cysteine Assay
|
Total
Cysteine Assay
|
So. Korea |
10-976967
|
|
Vitamin B6 Assay |
Homogeneous enzymatic assay for
vitamin B6 and improvements in H2S detection |
US
|
6,426,194 |
|
Vitamin B6 Assay |
Homogeneous enzymatic assay for
vitamin B6 and improvements in H2S detection |
Australia |
765,931 |
|
Vitamin B6 Assay |
Homogeneous enzymatic assay for
vitamin B6 and improvements in H2S detection |
Japan |
4,098,475 |
|
Vitamin B6 Assay |
Homogeneous enzymatic assay for
vitamin B6 and improvements in H2S detection |
China |
ZL 00803327.7 |
|
Vitamin B6 Assay |
Homogeneous enzymatic assay for
vitamin B6 and improvements in H2S detection |
China |
ZL 00803327.7 |
|
Folate Assay
|
Biological fluid assay methods
|
Canada
|
2361077
|
|
Folate Assay
|
Biological fluid assay methods
|
Europe |
1171630 |
|
Folate Assay
|
Biological fluid assay methods
|
Australia |
765,931 |
|
Folate Assay
|
Biological fluid assay methods
|
Australia |
2004200001 |
|
Folate Assay
|
Method
to determine hydrogen peroxide |
US
|
6,653,092
|
|
Folate Assay
|
Methods for
determining level of folate in a biological sample |
Canada
|
2,369,010
|
|
Folate Assay
|
Biological fluid assay methods |
Japan
|
5,462,427
|
|
Homocysteine therapeutic
|
Methods for treating and
reducing the potential for cardiovascular disease using methioninase
compositions
|
US
|
5,715,835
|
|
Homocysteine therapeutic
|
Use
of methioninase in anti-methionine
and anti-homocysteine chemotherapy
|
Europe
|
0839055
|
|
Homocysteine therapeutic
|
Use of methioninase in
anti-methionine and anti-homocysteine chemotherapy
|
Australia
|
708,361
|
|
Hair Pigmentation
Gene Therapy
|
Method and model for hair
pigmentation
|
US
|
6,372,489
|
|
Hair Pigmentation
Gene Therapy
|
Method and model for hair
pigmentation
|
Europe |
1127121
|
|
Gene Therapy
|
Selenium-containing
pro-drugs for cancer therapy |
US
|
6,653,278 |
|
Gene Therapy
|
Selenium-containing
pro-drugs for cancer therapy |
US
|
6,916,793 |
|
Gene Therapy
|
Methods for introducing genes into mammalian
subjects |
US
|
7,067,496 |
|
Gene Therapy
|
Selenium-containing
pro-drugs for cancer therapy |
Europe
|
1176968 |
|
Gene Therapy
|
Selenium-containing
pro-drugs for cancer therapy |
Australia |
784,612 |
|
Gene Therapy
|
Selenium-containing
pro-drugs for cancer therapy |
Canada |
2,372,992 |
|
Gene Therapy
|
Methods for
introducing genes into mammalian subjects |
Korea |
809312 |
|
In vitro model for HIV
infection and immune response |
Model for viral infection and
immune response |
US
|
6,551,772 |
|
In vitro model for HIV
infection and immune response |
In vitro model for HIV and
other viral diseases |
US
|
6,562,586 |
|
Stem Cells |
Angiogenesis
models using nestin-expressing stem cells to image nascent blood
vessels |
China
|
ZL200480039243.0 |
|
Stem Cells |
Angiogenesis
models using nestin-expressing stem cells to image nascent blood
vessels |
Europe
|
1677606 |
|
Stem Cells |
Angiogenesis
models using nestin-expressing stem cells to image nascent blood
vessels |
Japan |
5058602 |
|
Pancreatic
Cancer Treatment |
Use of a
pharmaceutical composition in the manufacture of a pharmaceutical
composition for treating pancreatic cancer |
China
|
ZL200480013774.2 |
|
Skin flap
model |
Enhanced
Resolution of Tumor Metastasis |
US |
7,625,550 |
|
Skin flap
model |
Enhanced
Resolution of Tumor Metastasis |
Japan |
4411068 |
|
Skin flap
model |
Enhanced
Resolution of Tumor Metastasis |
Australia |
2002326872 |
|
Skin flap
model |
Enhanced
Resolution of Tumor Metastasis |
Canada |
2,460,049 |
|
Skin flap
model |
Enhanced
Resolution of Tumor Metastasis |
Europe |
1435774 |
|
Bacterial
Therapy |
System for
monitoring bacterial tumor treatment |
US |
8,822,194 |
|
Bacterial
Therapy |
System for
monitoring bacterial tumor treatment |
Japan |
4350519 |
|
Bacterial
Therapy |
System for
monitoring bacterial tumor treatment |
Europe |
1461449 |
|
Bacterial
Therapy |
Cancer selective
auxotrophs |
Australia |
2005260697 |
|
Dual-color
model |
Immunocompromised rodents as dual-color tumor models |
US |
8,148,600 |
|
Dual-color
model |
Immunocompromised rodents as dual-color tumor models |
Australia |
2004212465 |
|
Methods for
identifying markers |
Methods for
identifying markers for early-stage human cancer, cancer progression
and recurrence |
Europe |
1954809 |
|
Angiogenesis Model |
Rapid in vivo model
for angiogenesis |
Europe |
2067031 |
|
Angiogenesis Model |
Rapid in vivo model
for angiogenesis |
Japan |
5484057 |
|
Dual-color model |
GFP and other
fluorescent protein transgenic nude mice |
Canada |
2,515,203 |
|
Dual-color model |
GFP and other
fluorescent protein transgenic nude mice |
Japan |
4658809 |
|
Dual-color model |
GFP and other
fluorescent protein transgenic nude mice |
Europe |
1590663 |
