ANTICANCER CLASSIC PUBLICATIONS

1. The first epigenetic alteration in an oncogene:

Cheah, M.S.C., Wallace, C.D. and Hoffman, R.M. Hypomethylation of DNA in human cancer cells: a site-specific change in the c-myc  onconegene. J. Natl. Cancer. Inst, 73, 1057-1065, 1984 [PDF] 

 

 2. FIRST GENERAL DEMONSTRATION OF REDUCED DNA METHYLATION IN HUMAN CANCER CELLS:

As Diala, E.S., Cheah, M.S.C., Rowitch, D. and Hoffman, R.M.  Extent of DNA methylation in human tumor cells.  J. Natl. Cancer Inst. 71, 755-764, 1983. [PDF]

 

3. FIRST MODEL OF CANCER EPIGENETICS:

Hoffman, R.M.  Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.  Biochim. Biophys. Acta 738, 49-87, 1984. [PDF]

 

4. DEVELOPMENT OF THE FIRST DNA LIPOSOMES FOR GENE THERAPY:

Hoffman, R.M., Margolis, L.B., and Bergelson, L.D. Binding and entrapment of high molecular weight DNA by lecithin liposomes. FEBS Letters 93, 365-368, 1978. [PDF]

5. FIRST CELL-TARGETED GENE THERAPY IN VIVO:

Li, L. and Hoffman, R.M.  The feasibility of targeted selective gene therapy of the hair follicle.  Nature Medicine 1, 705-706, 1995.[PDF]

 

6. FIRST PATIENT-LIKE MOUSE MODELS OF HUMAN CANCER:

Fu, X., Besterman, J.M., Monosov, A., and Hoffman, R.M. Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens. Proc. Natl. Acad. Sci. USA 88, 9345-9349, 1991.[PDF] 

 

7. FIRST PATIENT-LIKE MOUSE MODELS OF HUMAN CANCER:

Fu, X., and Hoffman, R.M. Human RT-4 bladder carcinoma is highly metastatic in nude mice and comparable to ras-H-transformed RT-4 when orthotopically onplanted as histologically intact tissue. Int. J. Cancer 51, 989-991, 1992. [PDF]

 

8. FIRST PATIENT-LIKE MOUSE MODELS OF HUMAN CANCER:

Hoffman, R.M. Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Investigational New Drugs 17, 343-359, 1999. [PDF]

 

9. DISCOVERY OF THE RATE-LIMITING STEP OF METASTASIS:

Kuo, T-H., Kubota, T., Watanabe, M., Furukawa, T., Teramoto, T., Ishibiki, K., Kitajimi, M., Moossa, A.R., Penman, S., Hoffman, R.M. Liver colonization competence governs colon cancer metastasis. Proc. Natl. Acad. Sci. USA 92, 12085-12089, 1995. [PDF]

 

10. FIRST USE OF GREEN FLUORESCENT PROTEIN FOR IN VIVO IMAGING:

Chishima, T., Miyagi, Y., Wang, X., Yamaoka, H., Shimada, H., Moossa, A.R., and Hoffman, R.M. Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression. Cancer Research 57, 2042-2047, 1997. [PDF]

 

11. FIRST USE OF GREEN FLUORESCENT PROTEIN FOR WHOLE-BODY IMAGING:

Yang, M., Baranov, E., Jiang, P., Sun, F-X., Li, X-M., Li, L., Hasegawa, S., Bouvet, M., Al-Tuwaijri, M., Chishima, T., Shimada, H., Moossa, A.R., Penman, S., Hoffman, R.M. Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases. Proc. Natl. Acad. Sci. USA 97, 1206-1211, 2000. [PDF]

 

12. FIRST USE OF GREEN FLUORESCENT PROTEIN FOR WHOLE-BODY IMAGING:

Hoffman, R.M. The multiple uses of fluorescent proteins to visualize cancer in vivo. Nature Reviews Cancer 5, 796-806, 2005.[PDF]

 

13. FIRST SUBCELLULAR IMAGING IN VIVO:

Yamamoto, N., Jiang, P., Yang, M., Xu, M., Yamauchi, K., Tsuchiya, H., Tomita, K., Wahl, G.M., Moossa, A.R., and Hoffman, R.M. Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Research 64, 4251-4256, 2004. [PDF]

 

14. FIRST SUBCELLULAR IMAGING IN VIVO:

Yamauchi, K., Yang, M., Jiang, P., Yamamoto, N., Xu, M., Amoh, Y., Tsuji, K., Bouvet, M., Tsuchiya, H., Tomita, K., Moossa, A.R., and Hoffman, R.M. Real-time in vivo dual-color imaging of intracapillary cancer cell and nucleus deformation and migration. Cancer Res. 65, 4246-4252, 2005. [PDF]

 

15. FIRST SUBCELLULAR IMAGING IN VIVO:

Yamauchi, K., Yang, M., Jiang, P., Xu, M., Yamamoto, N., Tsuchiya, H., Tomita, K., Moossa, A.R., Bouvet, M., and Hoffman, R.M. Development of real-time subcellular dynamic multicolor imaging of cancer cell trafficking in live mice with a variable-magnification whole-mouse imaging system. Cancer Res. 66, 4208-4214, 2006.[PDF]

 

16. DISCOVERY THAT HAIR FOLLICLE STEM CELLS CAN FORM NEURONS AND OTHER NEUROLOGICAL CELLS AND CAN BE USED FOR NERVE REPAIR:

Li, L., Mignone, J., Yang, M., Matic, M., Penman, S., Enikolopov, G., and Hoffman, R.M. Nestin expression in hair follicle sheath progenitor cells. Proc. Natl. Acad. Sci. USA 100, 9958-9961, 2003. [PDF]

 

17. DISCOVERY THAT HAIR FOLLICLE STEM CELLS CAN FORM NEURONS AND OTHER NEUROLOGICAL CELLS AND CAN BE USED FOR NERVE REPAIR: 

Amoh, Y., Li, L., Katsuoka, K., Penman, S., and Hoffman, R.M. Multipotent nestin-positive, keratin-negative hair-follicle-bulge stem cells can form neurons. Proc. Natl. Acad. Sci. USA 102, 5530-5534, 2005.[PDF]

 

18. DISCOVERY THAT HAIR FOLLICLE STEM CELLS CAN FORM NEURONS AND OTHER NEUROLOGICAL CELLS AND CAN BE USED FOR NERVE REPAIR: 

Amoh, Y., Li, L., Campillo, R., Kawahara, K., Katsuoka, K., Penman, S., and Hoffman, R.M. Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. Proc. Natl. Acad. Sci. USA 102, 17734-17738, 2005.[PDF]

 

19. DEVELOPMENT OF AN IN VITRO DRUG RESPONSE ASSAY FOR CANCER PATIENTS THAT PREDICTS PATIENT SURVIVAL:
Vescio, R.A., Redfern, C.H., Nelson, T.J., Ugoretz, S., Stern, P.H., and Hoffman, R.M. In vivo-like drug response of human tumors growing in three-dimensional, gel-supported, primary culture. Proc. Natl. Acad. Sci. USA 84, 5029-5033, 1987.[PDF]

 

20. DEVELOPMENT OF AN IN VITRO DRUG RESPONSE ASSAY FOR CANCER PATIENTS THAT PREDICTS PATIENT SURVIVAL:
Furukawa, T., Kubota, T., Hoffman, R.M. Clinical applications of the histoculture drug response assay. Clinical Cancer Research 1, 305-311, 1995. [PDF]

 

21. DEVELOPMENT OF AN IN VITRO DRUG RESPONSE ASSAY FOR CANCER PATIENTS THAT PREDICTS PATIENT SURVIVAL:

Kubota, T., Sasano, N., Abe, O., Nakao, I., Kawamura, E., Saito, T., Endo, M., Kimura, K., Demura, H., Sasano, H., Nagura, H., Ogawa, N., and Hoffman, R.M. Potential of the histoculture drug response assay to contribute to cancer patient survival. Clinical Cancer Research 1, 1537-1543, 1995.[PDF]

 

22. DEVELOPMENT OF BACTERIAL MONOTHERAPY FOR CANCER:

Zhao, M., Yang, M., Li, X-M., Jiang, P., Li, S., Xu, M., and Hoffman, R.M. Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium. Proc. Natl. Acad. Sci USA 102, 755-760, 2005. [PDF]