Olympus OV100, IV100 Publications

        1. Hoffman, R.M. Advantages of multi-color fluorescent proteins for whole-body and in vivo cellular imaging. Journal of Biomedical Optics 10(4), 41202, 2005.

2. Tsuji, K., Yamauchi, K., Yang, M., Jiang, P., Bouvet, M., Endo, H., Kanai, Y., Yamashita, K., Moossa, A.R., and Hoffman, R.M. Dual-color imaging of nuclear-cytoplasmic dynamics, viability, and proliferation of cancer cells in the portal vein area. Cancer Res. 66, 303-306, 2006.

3. Pilch, J., Brown, D.M., Komatsu, M., Järvinen, T., Yang, M., Peters, D., Hoffman, R.M., and Ruoslahti, E. Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds. Proc. Natl. Acad. Sci. USA 103, 2800-2804, 2006.

4. Tsuji, K., Yang, M., Jiang, P., Maitra, A., Kaushal, S., Yamauchi, K., Katz, M.D., Moossa, A.R., Hoffman, R.M, Bouvet, M. Common bile duct injection as a novel method for establishing RFP-expressing human pancreatic cancer in nude mice. Journal of the Pancreas 7, 193-199, 2006.

5. Yamauchi, K., Yang, M., Jiang, P., Xu, M., Yamamoto, N., Tsuchiya, H., Tomita, K., Moossa, A.R., Bouvet, M., and Hoffman, R.M. Development of real-time subcellular dynamic multicolor imaging of cancer cell trafficking in live mice with a variable-magnification whole-mouse imaging system. Cancer Res. 66, 4208-4214, 2006.

6. Amoh, Y., Li, L., Tsuji, K., Moossa, A.R., Katsuoka, K., Hoffman, R.M., Bouvet, M. Dual-color imaging of nascent blood vessels vascularizing pancreatic cancer in an orthotopic model demonstrates antiangiogenesis efficacy of gemcitabine. J. Surgical Research 132, 164-169, 2006.

7. Jiang, P., Yamauchi, K., Yang, M., Tsuji, K., Xu, M., Maitra, A., Bouvet, M., and Hoffman, R.M. Tumor cells genetically labeled with GFP in the nucleus and RFP in the cytoplasm for imaging cellular dynamics. Cell Cycle 5, 1198-1201, 2006.

8. Hoffman, R.M., and Yang, M. Subcellular imaging in the live mouse. Nature Protocols 1, 775-782, 2006.

9. Hoffman, R.M., and Yang, M. Color-coded fluorescence imaging of tumor-host interactions. Nature Protocols 1, 928-935, 2006.

10. Hoffman, R.M., and Yang, M. Whole-body imaging with fluorescent proteins. Nature Protocols 1, 1429-1438, 2006.

11. Zhao, M., Yang, M., Ma, H., Li, X., Tan, X., Li, S., Yang, Z., and Hoffman, R.M. Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice. Cancer Research 66, 7647-7652, 2006.

12. Hoffman, R.M. Real-time subcellular imaging in live animals: New visible targets for cancer drug discovery. IDrugs 9, 632-635, 2006.

13. Hoffman, R.M. AngioMouse: imageable models of angiogenesis. In: Angiogenesis Assays: A critical appraisal of current techniques, pp. 293-310. Staton, C.A., Lewis, C., and Bicknell, R., eds. Wiley and Sons, 2006 (Cover story).

14. Amoh, Y., Nagakura, C., Maitra, A., Moossa, A.R., Katsuoka, K., Hoffman, R.M., and Bouvet, M. Dual-color imaging of nascent angiogenesis and its inhibition in liver metastases of pancreatic cancer. Anticancer Research 26, 3237-3242, 2006.

15. Bouvet, M., Tsuji, K., Yang, M., Jiang, P., Moossa, A.R., and Hoffman, R.M. In vivo color-coded imaging of the interaction of colon cancer cells and splenocytes in the formation of liver metastases. Cancer Research 66, 11293-11297, 2006.

16. Hoffman, R.M. Multi-color fluorescence imaging of sub-cellular dynamics of cancer cells in live mice. Proc. of SPIE 6098, 60980D1-60980D7, 2006.

17. Amoh, Y., Bouvet, M., Li, L., Tsuji, K., Moossa, A.R., Katsuoka, K., and Hoffman, R.M. Visualization of nascent tumor angiogenesis in lung and liver metastasis by differential dual-color fluorescence imaging in nestin-linked-GFP mice. Clin. Exp. Metastasis 23(7-8), 315-322, 2006.

18. Hoffman, R.M. Subcellular imaging tracks cancer cells in mice. SPIE Newsroom, 2006. DOI: 10.117/2.1200608.0335.

19. Amoh, Y., Li, L., Moossa, A.R., Katsuoka, K., and Hoffman, R.M. Chemotherapy targets the hair-follicle vascular network but not the stem cells. J. Invest. Dermatol. 127, 11-15, 2007.

20. Hoffman, R.M., and Zhao, M. Whole-body imaging of bacterial infection and antibiotic response. Nature Protocols 1(6), 2988-2994, 2006.

21. Yang, M., Jiang, P., and Hoffman, R.M. Whole-body subcellular multicolor imaging. Proc. of SPIE 6449, 64490V-1 – 64490V-9, 2007.

22. Ji, Y., Hayashi, K., Amoh, Y., Tsuji, K., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Bouvet, M., and Hoffman, R.M. The camptothecin derivative CPT-11 inhibits angiogenesis in a dual-color imageable orthotopic metastatic nude mouse model of human colon cancer. Anticancer Res. 27, 713-718, 2007.

23. Yang, M., Jiang, P., and Hoffman, R.M. Whole-body subcellular multicolor imaging of tumor-host interaction and drug response in real time. Cancer Res. 67, 5195-5200, 2007.

24. Zhao, M., Geller, J., Ma, H., Yang, M., Penman, S., Hoffman, R.M. Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer. Proc. Natl. Acad. Sci. USA 104, 10170-10174, 2007.

25. Hayashi, K., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Amoh, Y., Hoffman, R.M., and Bouvet, M. Dual-color imaging of angiogenesis and its inhibition in bone and soft tissue sarcoma. J. Surg. Res. 140, 165-170, 2007.

26. Hayashi, K., Jiang, P., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Moossa, A.R., Bouvet, M., and Hoffman, R.M. Real-time imaging of tumor-cell shedding and trafficking in lymphatic channels. Cancer Res. 67, 8223-8228, 2007.

27. Yamauchi, K., Yang, M., Hayashi, K., Jiang, P., Yamamoto, N., Tsuchiya, H., Tomita, K., Moossa, A.R., Bouvet, M., and Hoffman, R.M. Imaging of nucleolar dynamics during the cell cycle of cancer cells in live mice. Cell Cycle 6, 2706-2708, 2007.

28. Hoffman, R.M. Recent advances on in vivo imaging with fluorescent proteins. In: Fluorescent Proteins, 2nd Edition, Vol. 85, pp. 485-495. Sullivan, K., ed. Series: Methods in Cell Biology, Wilson, L., and Matsudaira, P., eds, 2008.

29. Hoffman, R.M. A better fluorescent protein for whole-body imaging. Trends in Biotechnology 26, 1-4, 2008.

30. Yamauchi, K., Yang, M., Hayashi, K., Jiang, P., Yamamoto, N., Tsuchiya, H., Tomita, K., Moossa, A.R., Bouvet, M., and Hoffman, R.M. Induction of cancer metastasis by cyclophosphamide pretreatment of host mice: an opposite effect of chemotherapy. Cancer Res. 68, 516-520, 2008.

31. Hoffman, R.M. Imaging in mice with fluorescent proteins: from macro to subcellular. Sensors 8, 1157-1173, 2008.

32. Seitz, G., Warmann, S.W., Fuchs, J., Heitmann, H., Mahrt, J., Busse, A-C., Ruck, P., Hoffman, R.M., and Wessels, J.T. Imaging of cell trafficking and metastasis of paediatric rhabdomyosarcoma. Cell Proliferation 41, 365-374, 2008.

33. McElroy, M., Kaushal, S., Luiken, G., Moossa, A.R., Hoffman, R.M., and Bouvet, M. Imaging of primary and metastatic pancreatic cancer using a fluorophore-conjugated anti-CA19-9 antibody for surgical navigation. World Journal of Surgery 32, 1057-1066, 2008.

34. Hoffman, R.M. Use of GFP for in vivo imaging: concepts and misconceptions. Proc. of SPIE 6868, 68680E1-68680E7, 2008.

35. Yamauchi, K., Yang, M., Hayashi, K., Jiang, P., Xu, M., Yamamoto, N., Tsuchiya, H., Tomita, K., Moossa, A.R., Bouvet, M., and Hoffman, R.M. Imaging enhancement of malignancy by cyclophosphamide: surprising chemotherapy opposite effects. Proc. of SPIE 6868, 68680I1-68680I5, 2008.

36. Yang, M., Jiang, P., Al-Zaid, M., and Hoffman, R.M. Noninvasive imaging in vivo with fluorescent proteins from centimeters to micrometers. Proc. of SPIE 6868, 68680G1-68680G7, 2008.

37. McElroy, M., Kaushal, S., Bouvet, M., Hoffman, R.M. Color-coded imaging of splenocyte-pancreatic cancer cell interactions in the tumor microenvironment. Cell Cycle 7, 2916-2921, 2008.

38. Arrach, N., Zhao, M., Porwollik, S., Hoffman, R.M., and McClelland, M. Salmonella promoters preferentially activated inside tumors. Cancer Res. 68, 4827-4832, 2008.

39. Wessels, J.T., Hoffman, R.M., and Wouters, F.S. The use of transgenic fluorescent mouse strains, fluorescent protein coding vectors, and innovative imaging techniques in the life sciences. Cytometry A 73, 490-491, 2008.

40. Hoffman, R.M. In vivo real-time imaging of nuclear-cytoplasmic dynamics of dormancy, proliferation and death of cancer cells. Acta Pathologica, Microbiologica et Immunologica Scandinavica 116, 716-729, 2008.

41. McElroy, M., Bouvet, M., and Hoffman, R.M. Color-coded fluorescent mouse models of cancer cell interactions with blood vessels and lymphatics. In: Angiogenesis: In Vivo Systems, Pt. B, Methods in Enzymology, Vol. 445, pp. 27-52. Cheresh, D.A., ed. Elsevier, 2008.

42. McElroy, M., Kaushal, S., Bouvet, M., Hoffman, R.M. Color-coded imaging of splenocyte-pancreatic cancer cell interactions in the tumor microenvironment. Cell Cycle 7, 2916-2921, 2008.

43. Kaushal, S., McElroy, M.K., Luiken, G.A., Talamini, M.A., Moossa, A.R., Hoffman, R.M., and Bouvet, M. Fluorophore-conjugated anti-CEA antibody for the intraoperative imaging of pancreatic and colorectal cancer. J. Gastrointest. Surg. 12, 1938-1950, 2008.

44. Mehta S.R., Huang, R., Yang, M., Zhang, X-Q., Kolli, B., Chang, K-P., Hoffman, R.M., Goto, Y., Badaro, R., and Schooley, R.T. Real-time in vivo green fluorescent protein imaging of a murine leishmaniasis model as a new tool for Leishmania vaccine and drug discovery. Clinical and Vaccine Immunology 15, 1764-1770, 2008.

45. Amoh, Y., Katsuoka, K., and Hoffman, R.M. Color-coded fluorescent protein imaging of angiogenesis: the AngioMouse models. Curr. Pharm. Des. 14, 3810-3819, 2008.

46. McElroy, M., Hayashi, K., Garmy-Susini, B., Kaushal, S., Varner, J.A., Moossa, A.R., Hoffman, R.M., and Bouvet, M. Fluorescent LYVE-1 antibody to image dynamically lymphatic trafficking of cancer cells in vivo. J. Surg. Res. 151, 68-73, 2009.

47. Hayashi, K., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Bouvet, M., Wessels, J., and Hoffman, R.M. A color-coded orthotopic nude-mouse treatment model of brain-metastatic paralyzing spinal cord cancer that induces angiogenesis and neurogenesis. Cell Proliferation 42, 75-82, 2009.

48. Yang, M., Reynoso, J., Bouvet, M., and Hoffman, R.M. A transgenic red fluorescent protein-expressing nude mouse for color-coded imaging of the tumor microenvironment. J. Cell. Biochem. 106, 279-284, 2009.

49. Tran Cao, H.S., Kimura, H., Kaushal, S., Snyder, C.S., Reynoso, J., Hoffman, R.M., and Bouvet, M. The cyan fluorescent protein (CFP) transgenic mouse as a model for imaging pancreatic exocrine cells. Journal of the Pancreas 10, 152-156, 2009.

50. Hoffman, R.M. Imaging cancer dynamics in vivo at the tumor and cellular level with fluorescent proteins. Clin. Exp. Metastasis offman26, 345-355, 2009.

51. Hayashi, K., Zhao, M., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Kishimoto, H., Bouvet, M., and Hoffman, R.M. Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhymurium. Cell Cycle 8, 870-875, 2009.

52. Hayashi, K., Zhao, M., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., and Hoffman, R.M. Cancer metastasis directly eradicated by targeted therapy with a modified Salmonella typhymurium. J. Cell. Biochem. 106, 992-998, 2009.

53. Hoffman, R.M. Dual-color imaging of tumor angiogenesis. In: Methods in Molecular Biology, Vol. 515: Viral Applications of Green Fluorescent Protein, pp. 45-61. Hicks, Barry W., ed. New York, NY: Humana Press, 2009.

54. Makale, M., McElroy, M., O’Brien, P., Hoffman, R.M., Guo, S., Bouvet, M., Barnes, L., Ingulli, E., and Cheresh, D. Extended-working-distance multiphoton micromanipulation microscope for deep-penetration imaging in live mice and tissue. Journal of Biomedical Optics 14(2), 024032, 2009.

55. Snyder, C.S., Kaushal, S., Kono, Y., Tran Cao, H.S., Hoffman, R.M., and Bouvet, M. Complementarity of ultrasound and fluorescence imaging in an orthotopic mouse model of pancreatic cancer. BMC Cancer 9, 106, 2009.

56. Nagakura, C., Hayashi, K., Zhao, M., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Bouvet, M., and Hoffman, R.M. Efficacy of a genetically-modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice. Anticancer Res. 29, 1873-1878, 2009.

57. McElroy, M., Kaushal, S., Tran Cao, H.S., Moossa, A.R., Talamini, M.A., Hoffman, R.M., Bouvet, M. Upregulation of thrombospondin-1 and angiogenesis in an aggressive human pancreatic cancer cell line selected for high metastasis. Molecular Cancer Therapeutics 8, 1779-1786, 2009.

58. Kishimoto, H., Zhao, M., Hayashi, K., Urata, Y., Tanaka, N., Fujiwara, T., Penman, S., and Hoffman, R.M. In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation. Proc. Natl. Acad. Sci. USA, 106, 14514-14517, 2009.

59. Hoffman, R.M. Tumor-targeting amino-acid auxotrophic Salmonella typhimurium: A review. Special Amino Acids Microbiology Issue: Amino Acids 37(3), 509-521, 2009.

60. Bouvet, M., and Hoffman, R.M. Clinically-relevant orthotopic metastatic models of pancreatic cancer imageable with fluorescent genetic reporters. Minerva Chirurgica 64, 521-539, 2009

61. Kishimoto, H., Urata, Y., Tanaka, N., Fujiwara, T., and Hoffman, R.M. Selective metastatic tumor labeling with green fluorescent protein and killing by systemic administration of telomerase-dependent adenoviruses. Molecular Cancer Therapeutics 8, 3001-3008, 2009.

62. Amoh, Y., and Hoffman, R.M. Isolation and culture of hair follicle pluripotent stem (hfPS) cells and their use for nerve and spinal cord regeneration. In: Methods in Molecular Biology, Vol. 585: Epidermal Cells Methods and Protocols, 2nd edition, pp. 401-420. K. Turksen, ed. New York, NY: Humana Press, 2010.

63. Kimura, H., Hayashi, K., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Kishimoto, H., Bouvet, M., Hoffman, R.M. Real-time imaging of single cancer-cell dynamics of lung metastasis. J. Cell. Biochem. 109, 58-64, 2010.

64. Hasegawa, A., Hayashi, K., Kishimoto, H., Yang, M., Tofukuji, S., Suzuki, K., Nakajima, H., Hoffman, R.M., Shirai, M., and Nakayama, T. Color-coded real-time cellular imaging of lung T lymphocyte accumulation and focus formation in a mouse asthma model. J. Allergy Clin. Immunol .125, 461-468, 2010.

65. Logan-Collins, J., Thomas, R.M., Yu, P., Jaquish, D., Mose, E., French, R., Stuart, W., McClaine, R., Aronow, B., Hoffman, R.M., Waltz, S.E., and Lowy, A.M. Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers. Cancer Res. 70, 1130-40, 2010.

66. Zhang, Q., Yang, M., Shen, J., Gerhold, L.M., Hoffman, R.M., Xing, H.R. The role of the intravascular microenvironment in spontaneous metastasis development. International Journal of Cancer 126, 2534-2541, 2010.

67. Aki, R., Amoh, Y., Li, L., Katsuoka, K., and Hoffman, R.M. Nestin-expressing interfollicular blood vessel network contributes to skin transplant survival and wound healing. J. Cell. Biochem. 110, 80-86, 2010.

68. Tran Cao, H.S., Bouvet, M., Kaushal, S., Keleman, A., Romney, E., Kim, G., Fruehauf, J., Imagawa, D.K., Hoffman, R.M., and Katz, M. Metronomic gemcitabine in combination with Sunitinib inhibits multisite metastasis and increases survival in an orthotopic model of pancreatic cancer. Molecular Cancer Therapeutics 9, 2068-2078, 2010. (Highlights Section. Molecular Cancer Therapeutics 9, 1929, 2010).

69. Wessels, J.T., Yamauchi, K., Hoffman, R.M., and Wouters, F.S. Advances in cellular, subcellular, and nanoscale imaging in vitro and in vivo. Cytometry A 77, 667-676, 2010.

70. Kimura, H., Lee, C., Hayashi, K., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Bouvet, M., and Hoffman, R.M. UV light killing efficacy of fluorescent protein-expressing cancer cells in vitro and in vivo. J. Cell. Biochem 110, 1439-1446, 2010.

71. Tsai, M-H., Aki, R., Amoh, Y., Hoffman, R.M., Katsuoka, K., Kimura, H., Lee, C., and Chang, C-H. GFP-fluorescence-guided UVC irradiation inhibits melanoma growth and angiogenesis in nude mice. Anticancer Research 30, 3291-3294, 2010.

72. Suetsugu, A., Osawa, Y., Nagaki, M., Moriwaki, H., Saji, S., Bouvet, M., and Hoffman, R.M. Simultaneous color-coded imaging to distinguish cancer “stem-like” and non-stem cells in the same tumor. J. Cell. Biochem. 111, 1035-1041, 2010.

73. Yam, C., Zhao, M., Hayashi, K., Ma, H., Kishimoto, H., McElroy, M., Bouvet, M., and Hoffman, R.M. Monotherapy with a tumor-targeting mutant of S. typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer. J. Surg. Res. 164, 248-255, 2010.

74. Liu, F., Zhang, L., Hoffman, R.M., and Zhao, M. Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity. Cell Cycle 9, 4518-4524, 2010.

75. Tran Cao, H.S., Kaushal, S., Snyder, C.S., Ongkeko, W.M., Hoffman, R.M., and Bouvet, M. Real-time imaging of tumor progression in a fluorescent orthotopic mouse model of thyroid cancer. Anticancer Research 30, 4415-4422,

76. Erten, A., Hall, D., Hoh, C., Tran Cao, H.S., Kaushal, S., Esener, S., Hoffman, R.M., Bouvet, M., Chen, J., Kesari, S., and Makale, M. Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging. J. Biomed. Optics 15(6), 066012, 2010.

77. Kimura, H., Momiyama, M., Tomita, K., Tsuchiya, H., and Hoffman, R.M. Long-working-distance fluorescence microscope with high-numerical-aperture objectives for variable-magnification imaging in live mice from macro- to subcellular. J. Biomed. Optics 15(6), 066029, 2010.

78. Hoffman, R.M. Orthotopic mouse models expressing fluorescent proteins for cancer drug discovery. Expert Opin. Drug Discov. 5, 851-866, 2010.

79. Hoffman, R.M. Nestin-driven green fluorescent protein as an imaging marker for nascent blood vessels in mouse models of cancer. In: Light Microscopy. Methods in Molecular Biology 689. H. Chiarini-Garcia, R.C.N. Melo, eds. Springer Science+Business Media, LLC, 183-204, 2011

80. Suetsugu, A., Osawa, Y., Nagaki, M., Saji, S., Moriwaki, H., Bouvet, M., and Hoffman, R.M. Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer. J. Cell. Biochem. 112, 949-953, 2011.

81. Liu, F., Uchugonova, A., Kimura, H., Zhang, C., Zhao, M., Zhang, L., Koenig, K., Duong, J., Aki, R., Saito, N., Mii, S., Amoh, Y., Katsuoka, K., and Hoffman, R.M. The bulge area is the major hair follicle source of nestin-expressing pluripotent stem cells which can repair the spinal cord compared to the dermal papilla. Cell Cycle 10, 830-839, 2011.

82. Hoffman, R.M. Imaging the steps of metastasis at the macro and cellular level with fluorescent proteins in real time. In: Tumor Models in Cancer Research, Vol. 2, pp. 125-166. Teicher, B.A., ed. Humana Press (c/o Springer Science+Business Media LLC), 2011.

83. Yamamoto, N., Tsuchiya, H., and Hoffman, R.M. Tumor imaging with multicolor fluorescent protein expression. Int. J. Clin. Oncol. 16, 84-91, 2011.

84. Kolostova, K., Pinterova, D., Hoffman, R.M., and Bobek, V. Circulating human prostate cancer cells from an orthotopic mouse model rapidly captured by immunomagnetic beads and imaged by GFP expression. Anticancer Res. 31, 1535-1539, 2011.

85. Zhang, Q., Bindokas, V.P., Shen, J., Fan, H., Hoffman, R.M., Xing, H.R. Time-course imaging of therapeutic functional tumor vascular normalization by anti-angiogenic agents. Mol. Cancer Ther. 10, 1173-1184, 2011.

86. Kishimoto, H., Aki, R., Urata, Y., Bouvet, M., Momiyama, M., Tanaka, N., Fujiwara, T., and Hoffman, R.M. Tumor-selective adenoviral-mediated GFP genetic labeling of human cancer in the live mouse reports future recurrence after resection. Cell Cycle 10, 2737-2741, 2011.

87. Tran Cao, H.S., McElroy, M., Kaushal, S., Hoffman, R.M., and Bouvet, M. Imaging of the interaction of cancer cells and the lymphatic system. Advanced Drug Delivery Reviews 63, 886-889, 2011.

88. Grzesiak, J.J., Tran Cao, H.S., Burton, D.W., Kaushal, S., Vargas, F., Clopton, P., Snyder, C.S., Deftos, L.J., Hoffman, R.M., and Bouvet, M. Knockdown of the β1 integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis. International Journal of Cancer 129, 2905-2915, 2011.

89. Hassanein, M.K., Suetsugu, A., Saji, S., Moriwaki, H., Bouvet, M., Moossa, A.R., and Hoffman, R.M. Stem-like and non-stem human pancreatic cancer cells distinguished by morphology and metastatic behavior. Journal of Cellular Biochemistry 112, 3549-3554, 2011 (Cover story).

90. Hayashi, K., Kimura, H., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Kishimoto, H., Hasegawa, A., Bouvet, M., and Hoffman, R.M. Comparison of cancer-cell seeding, viability and deformation in the lung, muscle and liver, visualized by subcellular real-time imaging in the live mouse. Anticancer Res. 31, 3665-3672, 2011.

91. Yamauchi, K., Tome, Y., Yamamoto, N., Hayashi, K., Kimura, H., Tsuchiya, H., Tomita, K., Bouvet, M., and Hoffman R.M. Color-coded real-time subcellular fluorescence imaging of the interaction between cancer and host cells in live mice. Anticancer Res. 32, 39-43, 2012.

92. Amoh, Y., Hamada, Y., Katsuoka, K., and Hoffman, R.M. In vivo imaging of nuclear-cytoplasmic deformation and partition during cancer cell death due to immune rejection. J. Cell. Biochem. 113, 465-472, 2012 (Cover story)