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           Cellular Toxicity of the adenoviral methioninase gene (Ad-MET) and selenomethionine (SeMET) Combination

                       Methioninase Cancer Gene Therapy with Selenomethionine as Suicide Prodrug Subatrate. Cancer Research 61; 6805-6810, September 15, 2001

                         

1.            Hasegawa, S., Yang, M., Chishima, T., Shimada, H., Moossa, A.R., Hoffman, R.M.  In vivo tumor delivery of the green fluorescent protein gene to report future occurrence of metastasis. Cancer Gene Therapy 7, 1336-1340, 2000. [PDF] 

2.            Miki, K., Xu, M., An, Z., Wang, X., Yang, M., Al-Refaie, W., Sun, X., Baranov, E., Tan, Y., Chishima, T., Shimada, H., Moossa, A.R., Hoffman, R.M.  Survival efficacy of the combination of the methioninase gene and methioninase in a lung cancer orthotopic model.  Cancer Gene Therapy 7, 332-338, 2000. [PDF] 

3.            Miki, K., Al-Refaie, W., Xu, M., Jiang, P., Tan, Y., Bouvet, M., Zhao, M., Gupta, A., Chishima, T., Shimada, H., Makuuchi, M., Moossa, A.R., and Hoffman, R.M.  Methioninase gene therapy of human cancer cells is synergistic with recombinant methioninase treatment. Cancer Research 60, 2696-2702, 2000. [PDF] 

4.            Miki, K, Xu, M., Gupta, A., Ba, Y., Tan, Y., Al-Refaie, W., Bouvet, M., Makuuchi, M., Moossa, A.R., and Hoffman, R.M.  Methioninase cancer gene therapy with selenomethionine as suicide prodrug substrate.  Cancer Research 61, 6805-6810, 2001. [PDF]

5.     Masako Kamiyama, Yasushi Ichikawa, Takashi Ishikawa, Takashi Chishima, Satoshi Hasegawa, Yohei Hamaguchi, Yoji Nagashima, Yohei Miyagi, Masato Mitsuhashi, David Hyndman, Robert M Hoffman, Shigeo Ohki and Hiroshi Shimada   VEGF receptor antisense therapy inhibits angiogenesis and perotoneal dissemination of human gastric cancer in nude mice. Cancer Gene Therapy, 9, 197-201, 2002. [PDF] 

6.     Pirocanac, E.C., Nassirpour, R., Yang, M, Wang, J-W., Nardin, S.R., Gu, J., Fang, B., Moossa, A.R., Hoffman, R.M., and Bouvet, M. Bax-induction gene therapy of pancreatic cancer. J.Surg.Res. 106, 346-351, 2002.[PDF]

7.    Hoffman, R.M. Immune reactions in skin and hair follicle gene therapy. Molecular Therapy 7, 294-295, 2003.[PDF]

8.    Katz, M.H., Spivack, D.E., Takimoto, S., Fang, B., Burton, D.W., Moosa, A.R., Hoffman, R.M., and  Bouvet, M. Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter. Annals of Surgical Oncology 10, 762-772, 2003.[PDF]

9.    Yamamoto, N., Gupta, A., Xu, M., Miki, K., Tsujimoto, Y., Tsuchiya, H., Tomita, K., Moosa, A.R., and Hoffman, R.M. Methioninase gene therapy with selenomethionine induces apoptosis in bcl-2-overproducing lung cancer cells. Cancer Gene Therapy 10, 445-450, 2003. [PDF]

10.    Gupta, A., Miki, K., Xu, M., Yamamoto, N., Moosa, A.R., and Hoffman, R.M. Combination efficacy of doxorubicin and adenoviral methioninase gene therapy with prodrug selenomethionine. Anticancer Research 23, 1181-1188, 2003.