Fluorescence Guided Surgery and Laparoscopy Publications

1.      McElroy, M., Kaushal, S., Luiken, G., Moossa, A.R., Hoffman, R.M., and Bouvet, M. Imaging of primary and metastatic pancreatic cancer using a fluorophore-conjugated anti-CA19-9 antibody for surgical navigation. World Journal of Surgery 32, 1057-1066, 2008.

2.       Kaushal, S., McElroy, M.K., Luiken, G.A., Talamini, M.A., Moossa, A.R., Hoffman, R.M., and Bouvet, M. Fluorophore-conjugated anti-CEA antibody for the intraoperative imaging of pancreatic and colorectal cancer. J. Gastrointest. Surg. 12, 1938-1950, 2008.

3.    Kishimoto, H., H., Zhao, M., Hayashi, K., Urata, Y., Tanaka, N., Fujiwara, T., Penman, S., and Hoffman, R.M. In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation. Proc. Natl. Acad. Sci. USA, 106, 14514-14517, 2009. Green Surgery, Editors’ Choice, Science 325, 11 September 2009.

4.    Kishimoto, H., Urata, Y., Tanaka, N., Fujiwara, T., and Hoffman, R.M. Selective metastatic tumor labeling with green fluorescent protein and killing by systemic administration of telomerase-dependent adenoviruses. Molecular Cancer Therapeutics 8, 3001-3008, 2009.

5.    Tran Cao, H., Kaushal, S., Lee, C., Snyder, C.S., Thompson, K.J., Horgan, S., Talamini, M.A., Hoffman, R.M., Bouvet, M. Fluorescence laparoscopy imaging of pancreatic tumor progression in an orthotopic mouse model. Surg. Endo. 25, 48-54, 2011.

6.    Tran Cao, H.S., Kaushal, S., Menen, R.S., Metildi, C.A., Lee, C., Snyder, C.S., Talamini, M.A., Hoffman, R.M., and Bouvet, M. Submillimeter-resolution fluorescence laparoscopy of pancreatic cancer in a carcinomatosis mouse model visualizes metastases not seen with standard laparoscopy. J. Laparoendosc. Adv. Surg. Tech. A 21, 485-489, 2011 (Cover story).

7.    Kishimoto, H., Aki, R., Urata, Y., Bouvet, M., Momiyama, M., Tanaka, N., Fujiwara, T., and Hoffman, R.M. Tumor-selective adenoviral-mediated GFP genetic labeling of human cancer in the live mouse reports future recurrence after resection. Cell Cycle 10, 2737-2741, 2011.

8.    Tran Cao, H.S., McElroy, M., Kaushal, S., Hoffman, R.M., and Bouvet, M. Imaging of the interaction of cancer cells and the lymphatic system. Advanced Drug Delivery Reviews 63, 886-889, 2011.

9.    Bouvet, M., and Hoffman, R.M. Glowing tumors make for better detection and resection. Sci. Transl. Med. 3, 110sf10, 2011.

10.  Metildi, C.A., Kaushal, S., Lee, C., Hardamon, C.R., Snyder, C.S., Luiken, G.A., Talamini, M.A., Hoffman, R.M., and Bouvet, M. An LED light source and novel fluorophore combinations improve fluorescence laparoscopic detection of metastatic pancreatic cancer in orthotopic mouse models. J. Am. Coll. Surg. 214, 997-1007, 2012.

11.  Metildi, C.A., Kaushal, S., Hardamon, C.R., Snyder, C.S., Pu, M., Messer, K.S., Talamini, M.A., Hoffman, R.M., and Bouvet, M. Fluorescence-Guided Surgery Allows for More Complete Resection of Pancreatic Cancer, Resulting in Longer Disease-Free Survival Compared with Standard Surgery in Orthotopic Mouse Models. J. Am. Coll. Surg. 215, 126-136, 2012.

12.  Tran Cao, H.S., Kaushal, S., Metildi, C.A., Menen, R.S., Lee, C., Snyder, C.S., Messer, K., Pu, M., Luiken, G.A., Talamini, M.A., Hoffman, R.M., and Bouvet, M. Tumor-specific fluorescence antibody imaging enables accurate staging laparoscopy in an orthotopic model of pancreatic cancer. Hepatogastroenterology 59(118), 1994-1999, 2012. DOI: 10.5754/hge11836.

13.  Bouvet, M., Metildi, C.A., and Hoffman, R.M. Reply re: Fluorescence-guided surgery allows for more complete resection of pancreatic cancer, resulting in longer disease-free survival compared with standard surgery in orthotopic mouse models. J. Am. Coll. Surg. 215, 592-593, 2012.

14.  Momiyama, M., Kumamoto, T., Suetsugu, A., Kishimoto, H., Chishima, T., Tanaka, K., Akiyama, H., Ichikawa, Y., Bouvet, M., Endo, I., and Hoffman, R.M. Major liver resection stimulates stromal recruitment and metastasis compared with repeated minor resection. J. Surg. Res. 178, 280-287, 2012.

15.  Metildi, C.A., Kaushal, S., Snyder, C.S., Hoffman, R.M., and Bouvet, M. Fluorescence-guided surgery of human colon cancer increases complete resection resulting in cures in an orthotopic nude mouse model. J. Surg. Res. 179, 87-93, 2013.

16.  Momiyama, M., Hiroshima, Y., Suetsugu, A., Tome, Y., Mii, S., Yano, S., Bouvet, M., Chishima, T., Endo, I., and Hoffman, R.M. Enhanced resection of orthotopic red-fluorescent-protein-expressing human glioma by fluorescence-guided surgery in nude mice. Anticancer Res. 33, 107-112, 2013.

17.  Wu, J., Ma, R., Cao, H., Wang, Z., Jing, C., Sun, Y., Zhang, Y., Yang, Z., Hoffman, R.M., and Tang, J. Intraoperative imaging of metastatic lymph nodes using a fluorophore-conjugated antibody in a HER2/neu-expressing orthotopic breast cancer mouse model. Anticancer Research 33, 419-24, 2013.

18.  Metildi, C.A., Hoffman, R.M., and Bouvet, M. Fluorescence-guided surgery and fluorescence laporascopy for gastrointestinal cancers in clinically-relevant mouse models. Gastroenterol. Res. Pract. 2013, Article ID 290634, 8 pages, 2013.

19.  Maawy, A.A., Hiroshima, Y., Kaushal, S., Luiken, G.A., Hoffman, R.M., and Bouvet, M. Comparison of a chimeric anti-carcinoembryonic antigen antibody conjugated with visible or near-infrared fluorescent dyes for imaging pancreatic cancer in orthotopic nude mouse models. J. Biomed. Optics 18, 126016, 2013.

20.  Metildi, C.A., Tang, C.M., Kaushal, S., Leonard, S.Y., Magistri, P., Tran Cao, H.S., Hoffman, R.M., Bouvet, M., and Sicklick, J.S. In vivo fluorescence imaging of gastrointestinal stromal tumors using fluorophore-conjugated anti-KIT antibody. Ann. Surg. Oncol., Suppl 3:693-700, 2013. DOI: 10.1245/s10434-013-3172-6.

21.  Metildi, C.A., Kaushal, S., Pu, M., Messer, K.A., Luiken, G.A., Moossa, A.R., Hoffman, R.M., and Bouvet, M. Fluorescence-guided surgery with a fluorophore-conjugated antibody to carcinoembryonic antigen (CEA), that highlights the tumor, improves surgical resection and increases survival in orthotopic mouse models of human pancreatic cancer. Ann. Surg. Oncol. 21, 1405-1411, 2014.

22.  Hiroshma, Y., Maawy, A., Sato, S., Murakami, T., Uehara, F., Miwa, S., Yano, S., Momiyama, M., Chishima, T., Tanaka, K., Bouvet, M., Endo, I., and Hoffman, R.M. Hand-held high-resolution fluorescence imaging system for fluorescence-guided surgery of patient and cell-line pancreatic tumors growing orthotopically in nude mice. J. Surg. Res. 187, 510-517, 2014.

23.  Metildi, C.A., Kaushal, S., Luiken, G.A., Talamini, M.A., Hoffman, R.M., and Bouvet, M. Fluorescently-labeled chimeric anti-CEA antibody improves detection and resection of human colon cancer in a patient-derived orthotopic xenograft (PDOX) nude mouse model. J Surg. Oncol. 109, 451-458, 2014.

24.  Hiroshima, Y., Maawy, A., Metildi, C.A.., Zhang, Y., Uehara, F., Miwa, S., Yano, S., Sato, S., Murakami, T., Momiyama, M., Chishima, T., Tanaka, K., Bouvet, M., Endo, I., and Hoffman, R.M. Successful fluorescence-guided surgery on human colon cancer patient-derived orthotopic xenograft mouse models using a fluorophore-conjugated anti-CEA antibody and a portable imaging system. J. Laparoendosc. Adv. Surg. Tech. A 24, 241-247, 2014.

25.  Metildi, C.A., Kaushal, S., Luiken, G.A., Hoffman, R.M., and Bouvet, M. Advantages of fluorescence-guided laparoscopic surgery of pancreatic cancer labeled with fluorescent anti-carcinoembryonic antigen antibodies in an orthotopic mouse model. J Am. Coll. Surg. 219, 132-141, 2014.

26.  Maawy, A., Hiroshima, Y., Zhang, Y., Luiken, G.A., Hoffman, R.M., and Bouvet, M. Polyethylene glycol (PEG) conjugations of chimeric anti-carcinoembryonic antigen (CEA) labeled with near infrared (NIR) dyes enhances imaging of liver metastases in a nude-mouse model of human colon cancer. PLoS One 9, e97965, 2014.

27.  Maawy, A., Hiroshima, Y., Zhang, Y., Luiken, G.A., Hoffman, R.M., and Bouvet, M. Specific tumor labeling enhanced by polyethylene glycol linkage of near infrared dyes conjugated to a chimeric anti-carcinoembryonic antigen antibody in a nude mouse model of human pancreatic cancer. J. Biomed. Optics 19, 101504, 2014.

28.  Hiroshima, Y., Maawy, A., Zhang, Y., Sato, S., Murakami, T., Yamamoto, M., Uehara, F., Miwa, S., Yano, S., Momiyama, M., Chishima, T., Tanaka, K., Bouvet, M., Endo, I., and Hoffman, R.M. Fluorescence-guided surgery in combination with UVC irradiation cures metastatic human pancreatic cancer in orthotopic mouse models. PLoS One 9, e99977, 2014.