1.   Hoffman, R.M., Margolis, L.B., and Bergelson, L.D.  Binding and entrapment of high molecular weight DNA by lecithin liposomes.  Elsevier/North-Holland Biomedical Press, FEBS Letters 93, 365-368, 1978. [PDF]

2.    Li, L., Margolis, L.B., and Hoffman, R.M.  Native-state sponge-gel histoculture of intact 3-dimensional tissue for in vitro toxicity assays.  8th International CAAT Symposium, (ed.) Alan M. Goldberg, The Johns Hopkins University.  Alternative Methods in Toxicology 8, 311-316, 1991. [PDF]

3.    Li, L., and Hoffman, R.M.  Hair growth and hair follicle proliferation in histocultured mouse skin.  Annals of the New York Academy of Sciences, The Molecular and Structural Biology of Hair 642, 506-509, 1991. [PDF]

4.     Li, L., Margolis, L.B. and Hoffman, R.M.  Skin toxicity determined in vitro by three-dimensional, native-state histoculture.  Proc. Natl. Acad. Sci. USA 88, 1908-1912, 1991. [PDF]

5.     Li, L., Paus, R., Margolis, L.B., and Hoffman, R.M.  Hair growth in vitro from histocultured skin.   In Vitro Cell. Dev. Biol. 28A, 479-481, 1992. [PDF]

6.     Li, L., Paus, R., Margolis, L.B., and Hoffman, R.M.  Hair shaft elongation, follicle growth, and spontaneous regression in long-term, gelatin sponge-supported histoculture of human scalp skin.  Proc. Natl. Acad. Sci. USA 89, 8764-8768, 1992. [PDF]

7.     Li, L., Paus, R., Slominski, A., and Hoffman, R.M.  Skin histoculture assay for studying the hair cycle.  In Vitro Cell. Dev. Biol. 28A, 695-698, 1992. [PDF]

8.     Li, L., Lishko, V.K., Margolis, L.B., and Hoffman, R.M.  Product-delivering liposomes specifically target hair follicles in histocultured intact skin.  In Vitro Cell. Dev. Biol. 28A, 679-681, 1992. [PDF]

9.     Li, L., Lishko, V.K., and Hoffman, R.M.  Liposomes can specifically target entrapped melanin to hair follicles in histocultured skin.  In Vitro Cell Dev. Biol. 29A, 192-194, 1993. [PDF]

10.  Li, L., Lishko, V.K., and Hoffman, R.M.  Liposome targeting of high molecular weight DNA to the hair follicles of histocultured skin: A model for gene therapy of the hair growth processes.  In Vitro Cell Dev. Biol. 29A, 258-260, 1993. [PDF]

11.  Li, L. and Hoffman, R.M.  Histoculture radiometric in vitro hair growth assay.  In Vitro Cell. Dev. Biol. 29A, 449-450, 1993. [PDF]

12.  Li, L., Lishko, V., and Hoffman, R.M.  High efficiency liposome-mediated transfection of the tyrosinase gene  to cultured cells: A model for the gene therapy of hair color restoration.  In Vitro Cell. Dev. Biol. 30A, 135-138, 1994. [PDF]

13.  Paus, R., Kreja-Papa, N., Li, L., Czarnetski, B.M., and Hoffman, R.M.  Correlation of proteolytic activities of organ cultured intact mouse skin with defined hair cycle stages.  J. Derm. Sci. 7, 202-209, 1994. [PDF]

14.  Li, L. and Hoffman, R.M.  Model of selective gene therapy of hair growth: liposome targeting of the active Lac-Z gene to hair follicles of histocultured skin.  In Vitro Cell Dev. Biol. 31A, 11-13, 1995. [PDF]

15.  Li, L. and Hoffman, R.M.  The feasibility of targeted selective gene therapy of the hair follicle.  Nature Medicine 1, 705-706, 1995. [PDF]

16.  Zhang, L., Li, L., Hofmann, G.A., and Hoffman, R.M.  Depth-targeted efficient gene delivery and expression in the skin by pulsed electric fields:  an approach to gene therapy of skin aging and other diseases.  Biochemical and Biophysical Research Communications 220, 633-636, 1996. [PDF]  

17.  Li, L. and Hoffman, R.M.  Topical liposome delivery of molecules to hair follicles in mice.   J. Derm. Sci. 14, 101-108, 1997. [PDF]

18.  Zhang, L., Li, L., An, Z., Hoffman, R.M., and Hofmann, G.A.  In vivo transdermal delivery of  large molecules by pressure-mediated electroincorporation and electroporation: a novel method for drug/gene delivery. Bioelectrochemistry and Bioenergetics 42, 283-292, 1997. [PDF]

19.  Hoffman, R.M.  Topical liposome targeting of dyes, melanins, genes, and proteins selectively to hair follicles. J. Drug Targeting 5, 67-74, 1997. [PDF]

20.  Gene scientists give grey hair the brush-off.  The Sunday Times, London, 19 September 1999. [PDF]  

21.  Hoffman, R.M.  The hair follicle as a gene therapy target.  Nature Biotechnology 18, 20-21, 2000. [PDF]

22.  Wadmar, M.  Wash that gray right out of your hair.  Fortune, p. 40, February 7, 2000. [PDF]

23.  Friedman, Devin.  Tech 2010, A Catalog of the Near Future; The Makeup That Changes Your Identity. The New York Times Magazine, p. 56-57, June 11, 2000. [PDF]

24.  Zhao, M., Saito, N., Li, L., Baranov, E., Kondoh, H., Mishima, Y., Sugiyama, M., Katsuoka, K., Hoffman, R.M.  A novel approach to gene therapy of albino hair in histoculture with a retroviral Streptomyces tyrosinase gene.  Pigment Cell Research 13, 345-351, 2000. [PDF]

25.  Saito, N., Zhao, M., Li.L., Baranov, E., Yang, M., Ohta, Y., Katsuoka, K., Penman, S., and Hoffman R.M. High efficiency genetic modification of hair follicles and growing hair shafts. Proc. Natl. Acad. Sci USA  99, 1310-1314, 2002. [PDF]

26.  Hoffman, R.M. Immune reactions in skin anfd hair follicle gene therapy. Molecular Therapy 7, 294-295, 2003. [PDF]

27.  Li, L., Mignone, J., Yang. M., Matic, M., Penman, S., Enikolopov, G. Nestin Expression in hair follicle sheath progenitor cells. Proc. Natl. Acad. Sci. USA 100(17), 9958-9961, 2003. [PDF]

28.  Hoffman, R.M. Gene targeting of hair follicles. In: Hair Science and Technology, ISBN 2-9600376-0-X, pp.363-372. Van Neste, D., ed. Tournai, Belgium: Skinterface, 2003.

29.  Amoh, Y., Li, L., Yang, M., Moossa, A.R., Katsuoka, K., Penman, S., and Hoffman, R.M.  Nascent blood vessels in the skin arise from nestin-expressing hair follicle cells.  Proc. Natl. Acad. Sci. USA 101, 13291-13295, 2004 [PDF]

30.  Amoh, Y., Li, L., Yang, M., Jiang, P., Moossa, A.R., Katsuoka, K., Hoffman, R.M. Hair-follicle-derived blood vessels vascularize tumors in skin and are inhibited by doxorubicin.  Cancer Research 65, 2337-2343, 2005 [PDF]

31.  Hoffman, R.M.  Gene and stem cell therapy of the hair follicle.  In: Epidermal Cells: Methods and Protocols. Methods in Molecular Biology, Vol. 289, pp. 437-448. Turksen, K., ed.  Totowa, NJ: Humana Press, 2005.[PDF]

32.  Hoffman, R. M. The hair follicle and its stem cells as drug delivery targets. Expert Opinion Drug Delivery 3, 437-443, 2006 [PDF]

33.  Hoffman, R.M.  The potential of nestin-expressing hair follicle stem cells in regenerative medicine. Expert Opin. Biol. Ther. 7, 289-291, 2007. [PDF]  

34.  Hoffman, R.M.  The pluripotency of hair follicle stem cells.  Cell Cycle 5, 232-233, 2006. [PDF] 

35.  Amoh, Y., Li, L., Moossa, A.R., Katsuoka, K., and Hoffman, R.M.  Chemotherapy targets the hair-follicle vascular network but not the stem cells.  J. Invest. Dermatol. 127, 11-15, 2007.[PDF]

36.  Hoffman, R.M.  The potential of nestin-expressing hair follicle stem cells in regenerative medicine. Expert Opin. Biol. Ther. 7, 289-291, 2007. [PDF]

37.  Amoh, Y., Li, L., Katsuoka, K., and Hoffman, R.M.  Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function.  Cell Cycle 7, 1865-1869, 2008.[PDF] News: Supplemental Movie 1- Before treatment: Supplemental Movie 2- After treatment:

38.  Hoffman, R.M. The hair follicle stem cell as the paradigm multipotent adult stem cell. In: Vol: Stem Cell Research and Therapeutics, Shi, Y., and Clegg, D.O., eds., 275-287, 320-326. Series: Advances in Biomedical Research 1, Liu, J.H., ed. Dordrecht, The Netherlands: Springer, 2008. [PDF]

39.  Amoh, Y., Kanoh, M., Niiyama, S., Kawahara, K., Satoh, Y., Katsuoka, K., and Hoffman, R.M. Human and mouse hair follicles contain both multipotent and monopotent stem cells. Cell Cycle 8, 176-177, 2009. [PDF]

40.  Amoh, Y., Li, L., Katsuoka, K., and Hoffman, R.M. Multipotent nestin-expressing hair follicle stem cells. Journal of Dermatology 36, 1-9, 2009. [PDF]

41.  Amoh, Y., Kanoh, M., Niiyama, S., Hamada, Y., Kawahara, K., Sato, Y., Hoffman, R.M., and Katsuoka, K. Human hair follicle pluripotent stem (hfPS) cells promote regeneration of peripheral-nerve injury: An advantageous alternative to ES and iPS cells. J. Cell. Biochem. 107, 1016-1020, 2009. [PDF]

42.  Hoffman, R.M. Hair follicle pluripotent stem (hfPS) cells. In: Human Adult Stem Cells, Human Cell Culture 7, pp. 171-182. Masters, J.R., Palsson, B.O., eds. Dordrecht: Springer, 2009. [PDF]

43.  Amoh, Y., and Hoffman, R.M. Isolation and culture of hair follicle pluripotent stem (hfPS) cells and their use for nerve and spinal cord regeneration. In: Epidermal Cells, 2nd Edition, Vol. 585, pp. 401-420. Turksen, K., ed. New York, NY: Humana Press, 2010. [PDF]

44.  Aki, R., Amoh, Y., Li, L., Katsuoka, K., Hoffman, R.M. Nestin-expressing interfollicular blood vessel network contributes to skin transplant survival and wound healing. J Cell Biochem. 110(1), 80-86, 2010.

45.  Amoh, Y., Hamada, Y., Aki, R., Kawahara, K., Hoffman, R.M., Katsuoka, K. Direct transplantation of uncultured hair-follicle pluripotent stem (hfPS) cells promotes the recovery of peripheral nerve injury. J Cell Biochem. 110(1), 272-277, 2010.

46.  Amoh, Y., Li, L., Katsuoka, K., and Hoffman, R.M.  Embryonic development of hair follicle pluripotent stem (hfPS) cells.  Medical Molecular Morphology 43, 123-127, 2010. [PDF]

47.  Liu, F., Uchugonova, A., Kimura, H., Zhang, C., Zhao, M., Zhang, L., Koenig, K., Duong, J., Aki, R., Saito, N., Mii, S., Amoh, Y., Katsuoka, K., and Hoffman, R.M.  The bulge area is the major hair follicle source of nestin-expressing pluripotent stem cells which can repair the spinal cord compared to the dermal papilla.  Cell Cycle 10, 830-839, 2011.

48. Uchugonova, A., Duong, J., Zhang, N., König, K., and Hoffman, R.M.  The bulge area is the origin of nestin-expressing pluripotent stem cells of the hair follicle.  J. Cell. Biochem. 112, 2046-2050, 2011. DOI: 10.1002/jcb.23122.

49. Amoh, Y., Aki, R., Hamada, Y., Niiyama, S., Eshima, K., Kawahara, K., Sato, Y., Tani, Y., Hoffman, R.M., and Katsuoka, K.  Nestin-positive hair follicle pluripotent stem cells can promote regeneration of impinged peripheral nerve injury.  Journal of Dermatology 39, 33-38, 2012.

50. Amoh, Y., Mii, S., Aki, R., Hamada, Y., Kawahara, K., Hoffman, R.M., and Katsuoka, K.  Multipotent nestin-expressing stem cells capable of forming neurons are located in the upper, middle and lower part of the vibrissa hair follicle.  Cell Cycle 11, 3513-3517, 2012. [PDF]

51. Mii, S., Duong, J., Tome, Y., Uchugonova, A., Liu, F., Amoh, Y., Saito, N., Katsuoka, K., and Hoffman, R. M. The role of hair follicle nestin-expressing stem cells during whisker sensory-nerve growth in long-term 3D culture. J. Cell. Biochem. 114, 1674-1684, 2013.