Publications:

1.    Zhao, M., Yang, M., Li, X-M., Jiang, P., Li, S., Xu, M., and Hoffman, R.M.  Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP expressing Salmonella typhimurium.  Proc. Natl. Acad. Sci. USA 102, 755-760, 2005.  Taroncher-Oldenburg, G.  Research Highlights: Feed a bacterium, kill a tumor.  Nature Biotechnol. 23, 189, 2005.

2.      Zhao, M., Yang, M., Ma, H., Li, X., Tan, X., Li, S., Yang, Z., and Hoffman, R.M.  Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice.  Cancer Research 66, 7647-7652, 2006.

3.       Hoffman, R.M., and Zhao, M.  Whole-body imaging of bacterial infection and antibiotic response.  Nature Protocols 1(6), 2988-2994, 2006.

4.      Zhao, M., Geller, J., Ma, H., Yang, M., Penman, S., Hoffman, R.M.  Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer.  Proc. Natl. Acad. Sci. USA 104, 10170-10174, 2007.

5.      Arrach, N., Zhao, M., Porwollik, S., Hoffman, R.M., and McClelland, M.  Salmonella promoters preferentially activated inside tumors.  Cancer Res. 68, 4827-4832, 2008.

6.       Hayashi, K., Zhao, M., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Kishimoto, H., Bouvet, M., and Hoffman, R.M.  Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhymurium.   Cell Cycle 8, 870-875, 2009.

7.       Penman, S.  Killing metastasis with engineered bacteria.  Cell Cycle 8, 798, 2009.

8.      Hayashi, K., Zhao, M., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., and Hoffman, R.M.  Cancer metastasis directly eradicated by targeted therapy with a modified Salmonella typhymurium.      J. Cell. Biochem. 106, 992-998, 2009.

9.     Nagakura, C., Hayashi, K., Zhao, M., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Bouvet, M., and Hoffman, R.M.  Efficacy of a genetically-modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice.  Anticancer Res. 29, 1873-1878, 2009.

10.     Wade, N. New cancer treatment shows promise in testing.  New York Times, June 29, 2009.

11.      Hoffman, R.M.  Tumor-targeting amino-acid auxotrophic Salmonella typhimurium: A review.  Amino Acids 37, 509-521, 2009.

12.     Yam, C., Zhao, M., Hayashi, K., Ma, H., Kishimoto, H., McElroy, M., Bouvet, M., Hoffman, R.M.  Monotherapy with a tumor-targeting mutant of S. typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer.  J. Surg. Res., Epub ahead of print, 2009.

13.   Kimura, H., Zhang, L., Zhao, M., Hayashi, K., Tsuchiya, H., Tomita, K., Bouvet, M., Wessels, J., and Hoffman, R.M.  Targeted therapy of spinal cord glioma with a genetically-modified Salmonella typhimurium.  Cell  Proliferation 43, 41-48, 2010.

14.  Arrach, N., Cheng, P., Zhao, M., Santiviago, C.A., Hoffman, R.M., and McClelland, M.  High-throughput screening for Salmonella avirulent mutants that retain targeting of solid tumors.  Cancer Res. 70, 2165-2170, 2010.

15.  Yam, C., Zhao, M., Hayashi, K., Ma, H., Kishimoto, H., McElroy, M., Bouvet, M., Hoffman, R.M. Monotherapy with a tumor-targeting mutant of S. typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer. J. Surg. Res. 164, 248-255, 2010.

16.  Liu, F., Zhang, L., Hoffman, R.M., and Zhao, M. Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity. Cell Cycle 9, 4518-4524, 2010.

17.   Dolgin, E.  From spinach scare to cancer care.  Nature Medicine 17, 273-275, 2011.  DOI: 10.1038/nm0311-273.

18.   Hoffman, R.M.  Tumor-seeking Salmonella amino acid auxotrophs.  Current Opinion in Biotechnology 22, 917-923, 2011.

19.   Hoffman, R.M.  The preclinical discovery of bacterial therapy for the treatment of metastatic cancer with unique advantages.  Expert Opinion on Drug Discovery 7, 73-83, 2012.

20.   Hoffman, R.M.  Targeting cancer with amino-acid auxotroph Salmonella typhimurium A1-R.  In: Bacteria and Cancer, Chapter 9, pp. 209-223.  Khan, A.A., ed.  Springer Science+Business Media B.V., 2012.

21.   Zhao, M., Suetsugu, A., Ma, H., Zhang, L., Liu, F., Zhang, Y., Tran, B., and Hoffman, R.M.  Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetent mice.  Cell Cycle 11, 187-193, 2012.

22.   Momiyama, M., Zhao, M., Kimura, H., Tran, B., Chishima, T., Bouvet, M., Endo, I., and Hoffman R.M.  Inhibition and eradication of human glioma with tumor-targeting Salmonella typhimurium in an orthotopic nude-mouse model.  Cell Cycle 11, 628-632, 2012.

23.  Zhang, Y., Tome, Y., Suetsugu, A., Zhang, L., Zhang, N., Hoffman, R.M., and Zhao M.  Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice.  Anticancer Research 32, 2501-2508, 2012.

24.   Hoffman, R.M.  Bugging Tumors.  Cancer Discovery 2(7), 588-590, 2012.

25.   Uchugonova, A., Zhao, M., Zhang, Y., Weinigel, M., König, K., and Hoffman, R.M.  Cancer-cell killing by engineeredSalmonella imaged by multiphoton tomography in live mice.  Anticancer Res. 32, 4331-4338, 2012.

26.   Tome, Y., Zhang, Y., Momiyama, M., Maehara, H., Kanaya, F., Tomita, K., Tsuchiya, H., Bouvet, M., Hoffman, R.M.., and Zhao, M.  Primer dosing of S. typhimurium A1-R potentiates tumor-targeting and efficacy in immunocompetent mice.  Anticancer Res. 33, 97-102, 2013.

27.   Zhang, Y., Zhang, N., Su, S., Hoffman, R.M., Zhao, M. Salmonella typhimurium A1-R tumor targeting in immunocompetent mice is enhanced by a Traditional Chinese Medicine herbal mixture. Anticancer Res. 33, 1837-1843, 2013.

28.   Hoffman, R.M. Tumor growth control with IDO-silencing Salmonella—Letter. Cancer Res. 73, 4591, 2013.

29.   Hiroshima, Y., Zhao, M., Zhang, Y., Maawy, A., Hassanein, M.K., Uehara, F., Miwa, S., Yano, S., Momiyama, M., Suetsugu, A., Chishima, T., Tanaka, K., Bouvet, M., Endo, I., and Hoffman, R.M. Comparison of efficacy of Salmonella typhimurium A1-R and chemotherapy on stem-like and non-stem human pancreatic cancer cells. Cell Cycle 12, 2774-2780, 2013.

30.   Binder, D.C., Engels, B., Arina, A., Yu, P., Stauch, J.M., Fu, Y-X, Karrison, T., Burnette, B., Idel, C., Zhao, M., Hoffman, R.M., Munn, D.H., Rowley, D.A., and Schreiber, H. Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer. Cancer Immunol. Res., 1, 123-133, 2013.

31.   Hiroshima, Y., Zhao, M., Maawy, A., Zhang, Y., Katz, M.H., Fleming, J.B., Uehara, F., Miwa, S., Yano, S., Momiyama, M., Suetsugu, A., Chishima, T., Tanaka, K., Bouvet, M., Endo, I., and Hoffman, R.M. Efficacy of Salmonella typhimurium A1-R versus chemotherapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX). J. Cell. Biochem. 115, 1254-1261, 2014.

32.   Hoffman, R.M., and Zhao, M. Methods for the development of tumor-targeting bacteria. Expert Opin Drug Discov 9(7), 741-750, 2014.

33.   Leslie, M. Bacteria shrink tumors in humans, dogs. Science (http://news.sciencemag.org/biology/2014/08/bacteria-shrink-tumors-humans-dogs), 13 August 2014.

34.   Matsumoto, Y., Miwa, S., Zhang, Y., Hiroshima, Y., Yano, S., Uehara, F., Yamamoto, M., Toneri, M., Bouvet, M., Matsubara, H., Hoffman, R.M., Zhao, M. Efficacy of tumor-targeting Salmonella typhimurium A1-R on nude mouse models of metastatic and disseminated human ovarian cancer. J. Cell. Biochem. 115, 1996-2003, 2014.

35.   Miwa, S., Yano, S., Zhang, Y., Matsumoto, Y., Uehara, F., Yamamoto, M.,Hiroshima, Y., Kimura, H., Hayashi, K., Yamamoto, N., Bouvet, M., Tsuchiya, H., Hoffman, R.M., Zhao, M. Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice. Oncotarget 5, 7119-7125, 2014.