AngioMouse PublicationsŪ

1.    Yang, M., Baranov, E., Li, X-M., Wang, J-W., Jiang, P., Li, L., Moossa, A.R., Penman, S., Hoffman, R.M. Whole‑body and intravital optical imaging of angiogenesis in orthotopically implanted tumors. Proc. Natl. Acad. Sci. USA 98, 2616-2621, 2001.

2.    Yang, M., Baranov, E., Wang, J-W., Jiang, P., Wang, X., Sun, F-X., Bouvet, M., Moossa, A.R., Penman, S., and Hoffman, R.M. Direct external imaging of nascent cancer, tumor progression, angiogenesis, and metastasis on internal organs in the fluorescent orthotopic model. Proc. Natl. Acad. Sci. USA 99, 3824-3829, 2002.

3.    Yang, M., Li, L., Jiang, P., Moossa, A.R., Penman, S., and Hoffman, R.M. Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells. Proc. Natl. Acad. Sci. USA 100, 14259-14262, 2003.

4.    Amoh, Y., Li, L., Yang, M., Moossa, A.R., Katsuoka, K., Penman, S., and Hoffman, R.M. Nascent blood vessels in the skin arise from nestin-expressing hair follicle cells. Proc. Natl. Acad. Sci. USA 101, 13291-13295, 2004.

5.    Yang, M., Reynoso, J., Jiang, P., Li, L., Moossa, A.R., and Hoffman, R.M. Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors. Cancer Research 64, 8651-8656, 2004.

6.    Hoffman, R.M. The multiple uses of fluorescent proteins to visualize cancer in vivo. Nature Reviews Cancer 5, 796-806, 2005.

7.    Amoh, Y., Li, L., Yang, M., Jiang, P., Moossa, A.R., Katsuoka, K., and Hoffman, R.M. Hair follicle-derived blood vessels vascularize tumors in skin and are inhibited by doxorubicin. Cancer Res. 65, 2337-2343. 2005.

8.    Amoh, Y., Yang, M., Li, L., Reynoso, J., Bouvet, M., Moossa, A.R., Katsuoka, K., and Hoffman, R.M. Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis. Cancer Res. 65, 5352-5357, 2005.

9.    Hoffman, R.M., and Yang, M.  Color-coded fluorescence imaging of tumor-host interactions.  Nature Protocols 1, 928-935, 2006.

10.  Amoh, Y., Li, L., Tsuji, K., Moossa, A.R., Katsuoka, K., Hoffman, R.M., Bouvet, M.  Dual-color imaging of nascent blood vessels vascularizing pancreatic cancer in an orthotopic model demonstrates antiangiogenesis efficacy of gemcitabine.  J. Surgical Research 132, 164-169, 2006.

11.  Amoh, Y., Nagakura, C., Maitra, A., Moossa, A.R., Katsuoka, K., Hoffman, R.M., and Bouvet, M.  Dual-color imaging of nascent angiogenesis and its inhibition in liver metastases of pancreatic cancer. Anticancer Research 26, 3237-3242, 2006.

12.  Amoh, Y., Bouvet, M., Li, L., Tsuji, K., Moossa, A.R., Katsuoka, K., and Hoffman, R.M.  Visualization of nascent tumor angiogenesis in lung and liver metastasis by differential dual-color fluorescence imaging in nestin-linked-GFP mice.  Clin. Exp. Metastasis 23(7-8), 315-322, 2006.

13.  Hoffman, R.M. AngioMouse: imageable models of angiogenesis. In: Angiogenesis Assays: A critical appraisal of current techniques, pp. 293-310. Staton, C.A., Lewis, C., and Bicknell, R., eds. Wiley and Sons, 2006.

14.  Amoh, Y., Li, L., Katsuoka, K., Bouvet, M., and Hoffman, R.M.  GFP-expressing vascularization of Gelfoam as a rapid in vivo assay of angiogenesis stimulators and inhibitors.    BioTechniques 42, 294-298, 2007.

15.  Ji, Y., Hayashi, K., Amoh, Y., Tsuji, K., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Bouvet, M., and Hoffman, R.M.  The camptothecin derivative CPT-11 inhibits angiogenesis in a dual-color imageable orthotopic metastatic nude mouse model of human colon cancer.  Anticancer Res. 27, 713-718, 2007.

16.  Hayashi, K., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Amoh, Y., Hoffman, R.M., and Bouvet, M. Dual-color imaging of angiogenesis and its inhibition in bone and soft tissue sarcoma. J. Surg. Res. 140, 165-170, 2007.

17.  Hayashi, K., Jiang, P., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Moossa, A.R., Bouvet, M., and Hoffman, R.M. Real-time imaging of tumor-cell shedding and trafficking in lymphatic channels. Cancer Res. 67, 8223-8228, 2007.

18.  Amoh, Y., Katsuoka, K., and Hoffman, R.M. Color-coded fluorescent protein imaging of angiogenesis: the AngioMouse models. Curr. Pharm. Des. 14, 3810-3819, 2008.

19.  Hayashi, K., Yamauchi, K., Yamamoto, N., Tsuchiya, H., Tomita, K., Bouvet, M., Wessels, J., and Hoffman, R.M. A color-coded orthotopic nude-mouse treatment model of brain-metastatic paralyzing spinal cord cancer that induce angiogenesis and neurogenesis. Cell Proliferation 42, 75-82, 2009.

20.  Yang, M., Reynoso, J., Bouvet, M., and Hoffman, R.M. A transgenic red fluorescent protein-expressing nude mouse for color-coded imaging of the tumor microenvironment. J. Cell. Biochem. 106, 279-284, 2009.

21.  Daenen, L.G., Shaked, Y., Man, S., Xu, P., Voest, E.E., Hoffman, R.M., and Kerbel, R.S.  Low-dose metronomic cyclophosphamide combined with vascular disrupting therapy induces potent antitumor activity in preclinical human tumor xenograft models.  Molecular Cancer Therapeutics 8, 2872-2881, 2009.

22.  Folkins, C., Shaked, Y., Man, S., Tang, T., Lee, C.R., Zhu, Z., Hoffman, R.M., and Kerbel, R.S.  Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1.  Cancer Research 69, 7243-7251, 2009.

23.   Aki, R., Amoh, Y., Li, L., Katsuoka, K., Hoffman, R.M.  Nestin-expressing interfollicular blood vessel network contributes to skin transplant survival and wound healing.  J Cell Biochem. 110(1), 80-86, 2010.

24.   Liu, F., Zhang, L., Hoffman, R.M., and Zhao, M.  Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity.  Cell Cycle 9, 4518-4524, 2010.

25.  Kioi, M., Vogel, H., Schultz, G., Hoffman, R.M., Harsh, G.R., and Brown, J.M.  Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma following irradiation in mice.   Journal of Clinical Investigation  120, 694-705, 2010.

26.  Soda, Y., Marumoto, T., Friedmann-Morvinski, D., Soda, M., Liu, F., Michiue, H., Pastorino, S., Yang, M., Hoffman, R.M., Kesari, S., Verma, I.M.  Transdifferentiation of glioblastoma cells into vascular endothelial cells.  Proc. Natl. Acad. Sci. USA108, 4274-4280, 2011. Commentary:  Hormigo, A., Ding, B-S., and Rafii, S.  A target for antiangiogenic therapy: Vascular endothelium derived from glioblastoma.  Proc. Natl. Acad. Sci. USA 108, 4271-4272, 2011.

27.  Zhang, Q., Bindokas, V.P., Shen, J., Fan, H., Hoffman, R.M., Xing, H.R.  Time-course imaging of therapeutic functional tumor vascular normalization by anti-angiogenic agents.  Mol. Cancer Ther. 10, 1173-1184, 2011.

28.  Tome, Y., Zhang, Y., Momiyama, M., Maehara, H., Kanaya, F., Tomita, K., Tsuchiya, H., Bouvet, M., Hoffman, R.M.., and Zhao, M. Primer dosing of S. typhimurium A1-R potentiates tumor-targeting and efficacy in immunocompetent mice. Anticancer Res. 33, 97-102, 2013.

29.  Shi, Y., Tong, M., Wu, Y., Yang, Z., Hoffman, R.M., Zhang, Y., Tian, Y., Qi, M., Lin, Y., Liu, Y., Dai, L., Sun, Y., and Wang, Z. VEGF-C ShRNA inhibits pancreatic cancer growth and lymphangiogenesis in an orthotopic fluorescent nude mouse model. Anticancer Research 33, 409-417, 2013.

30.  Uehara, F., Tome, Y., Yano, S., Miwa, S., Mii, S., Hiroshima, Y., Bouvet, M., Maehara, H., Kanaya, F., and Hoffman, R.M. A color-coded imaging model of the interaction of αv integrin-GFP expressed in osteosarcoma cells and RFP expressing blood vessels in GelfoamŪ vascularized in vivo. Anticancer Res. 33, 1361-1366, 2013.

31.  Uehara, F., Tome, Y., Reynoso, J., Mii, S., Yano, S., Miwa, S., Bouvet, M., Maehara, H., Kanaya, F., Moossa, A.R., and Hoffman, R.M. Color-coded imaging of spontaneous vessel anastomosis in vivo. Anticancer Research 33, 3041-3045.